\defaultfontfeatures{Ligatures=TeX}
\setmainfont[SmallCapsFeatures={Numbers=OldStyle},%
  NFSSFamily=MinionPro,%
  ItalicFont=MinionPro-It,%
  BoldFont=MinionPro-Bold,%
  BoldItalicFont=MinionPro-BoldIt,%
]{MinionPro-Regular}
\setsansfont[SmallCapsFeatures={Numbers=OldStyle},%
  NFSSFamily=MyriadPro,%
  ItalicFont=MyriadPro-It,%
  BoldFont=MyriadPro-Bold,%
  BoldItalicFont=MyriadPro-BoldIt,%
]{MyriadPro-Regular}
\newfontfamily{\greekfont}[SmallCapsFont=fspmnscel,%
  ItalicFont=MinionPro-It,%
  BoldFont=MinionPro-Bold,%
  BoldItalicFont=MinionPro-BoldIt,%
]{MinionPro-Regular}

\newfontfamily{\defaultfont}[SmallCapsFeatures={Numbers=OldStyle},%
  NFSSFamily=MinionPro,%
  ItalicFont=MinionPro-It,%
  BoldFont=MinionPro-Bold,%
  BoldItalicFont=MinionPro-BoldIt,%
]{MinionPro-Regular}


\setmathfont{STIXTwoMath-Regular.otf}
\setmathfont[range=\mathup/{num,latin,Latin,greek,Greek}]{MinionPro-Regular} 
\setmathfont[range=\mathbfup/{num,latin,Latin,greek,Greek}]{MinionPro-Bold} 
\setmathfont[range=\mathit/{num,latin,Latin,greek,Greek}]{MinionPro-It} 
\setmathfont[range=\mathbfit/{num,latin,Latin,greek,Greek}]{MinionPro-BoldIt}